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KMID : 1123920020160030514
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 3 p.514 ~ p.520
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The Effect of Paljinhangahm-dan on Human Promyelocytic Leukemia Cells(HL-60) Death
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Lee Gun-Up
Moon Seok-Jae
Moon Goo
Won Jin-Hee
Kim Dong-Woung
Kim Hyeong-Kyun
Moon Young-Ho
Lee Jong-Bum
Yoon Jun-Chul
Kim Hong-Joon
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Abstract
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Paljinhangahm-dan is an Oriental herbal formulation for its ability to modulate cancer cell growth and survival. This research was performed to study the anti-cancer effects of Paljinhangahm-dan water extract(PHWE) in human pro myelocytic leukemia(HL-60) cells. After HL-60 cells were routinely cultured, tetrazolium-based colorimetric(MTT) assay was performed for cytotoxicity test. To explore the mechanism of cytotoxicity. I used several measures of apoptosis to determine whether this processes was involved in PHWE-induced cell death in HL-60 cells. In addition, the experiment was practised 1 H-NMR spectroscopy to examine molecular structure of PHWE. This study suggested that PHWE control cancer cell growth through of apoptosis with less cytotoxicity in normal cells.
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KEYWORD
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Paljinhangahm-dan(人珍抗癌丹), anti-cancer effects, apoptosis, HL-60
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